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Ultrastructure of human primary hepatic carcinoma
Author(s) -
Toker Cyril,
Trevino Norberto
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196611)19:11<1594::aid-cncr2820191125>3.0.co;2-o
Subject(s) - endoplasmic reticulum , golgi apparatus , pathology , cytoplasm , ultrastructure , biology , mitochondrion , basement membrane , anatomy , microbiology and biotechnology , medicine
Two specimens of human primary hepatic carcinoma examined electron microscopically revealed abnormalities of cytoplasmic components; the abnormalities were dissimilar, however. Mitochondria showed aberration of shape and structure of cristae in one case and marked reduction in number with variation in size but with a uniformly spherical outline in the other. A polar distribution of mitochondria was noted within occasional cells. Rough surfaced endoplasmic reticulum was normal in one case but depleted in the other. Smooth endoplasmic reticulum showed mild pleomorphism in one neoplasm but marked disarray in the other, in which it formed large dilated cisternae. Cell and nuclear membranes, Golgi apparatus, ribosomes and chromatin were ultrastructurally normal. Nuclei were abnormal in shape, but their fine structure was normal. Bile canaliculi were numerous, lined by blunt short microvilli and contained bile pigment. Acidophilic bodies derived from necrosis of entire hepatocytes were noted and ingested fragments were seen within macrophages. Focal cytoplasmic necrosis also was observed. Sinusoidal lining cells were normal in structure but overlapped one another to produce a stratified lining. In areas basement membrane material was discernible. Both tumors thus presented abnormalities of the nuclei and mitochondria and one showed marked aberration of the endoplasmic reticulum. The latter tumor represented a further deviation from the normal than the former.