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Endometrial lavage as an aid in the cytochemical detection of adenocarcinomata
Author(s) -
Montanari G. D.,
Marconato A.,
Grismondi G. L.,
Giaretta M. I.,
Montanari Gioia R.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196611)19:11<1578::aid-cncr2820191120>3.0.co;2-t
Subject(s) - medicine , pathology , cytology , cytopathology , therapeutic irrigation , vaginal smear , cytological techniques , radiology , estrous cycle
In 59 patients with malignant neoplasias of the uterine cavity and/or the upper portion of the cervical canal an evaluation was made of the diagnostic accuracy of a cytochemical method based on the demonstration of a high SDH or DPND content in the neoplastic cells. These exfoliated cells were collected by lavage in a solution of a tetrazolium salt. The neoplastic cells were recognizable in the sediment of the lavage fluid by microscopic examination, because the cytoplasm exhibited an intense red‐stained reaction due to the oxidative enzymes present in a much higher quantity than it is usually found in rapidly proliferating non‐neoplastic cells. The cervico‐vaginal lavage method was not sufficiently accurate for the detection of endometrial carcinoma since it gave poorer results than cytologic smears from the pool. The endometrial lavage method, used in 32 patients plus 61 controls free from malignant tumors of the genital organs had a satisfactory diagnostic accuracy although the control group gave a high percentage of false‐positive results.