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Neoplastic disease and thyrotoxicosis
Author(s) -
Wanebo Harold J.,
Benua Richard S.,
Rawson Rulon W.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196611)19:11<1523::aid-cncr2820191110>3.0.co;2-d
Subject(s) - medicine , incidence (geometry) , breast cancer , malignancy , cancer , thyroid cancer , disease , oncology , dermatology , physics , optics
The relationship of thyrotoxicosis and malignancy has been studied in a cancer center. There was a lower incidence of cancer in patients with hyperthyroidism (25%) than in admissions generally (59.8%) but this probably represents a sampling difference. Of 300 women with thyrotoxicosis, 83 had neoplastic disease. Of the women with hyperthyroidism and cancer (excluding thyroid and skin malignancies), 56% had breast primaries. This is significantly different from the 36% incidence of breast cancer among all women with malignant neoplasms at the center. The incidence of hyperthyroidism was only 0.25% in females with breast cancer but the diagnosis of both diseases was made in 21 of 40 women within the same year. Such a time‐linked occurrence is statistically significant. No effect on survival was demonstrated. The significance of these findings is discussed.