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Anatomic distribution and grading of carcinoma in situ of the cervix
Author(s) -
Hajdu Steven I.,
Adelman Howard C.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196610)19:10<1466::aid-cncr2820191020>3.0.co;2-7
Subject(s) - medicine , grading (engineering) , biopsy , hysterectomy , atypia , carcinoma in situ , cervix , radiology , carcinoma , pathology , cancer , civil engineering , engineering
One hundred cervical cone biopsies and the subsequent hysterectomized uteri were studied. In each case the diagnosis of carcinoma in situ (CIS) was established on the cone biopsy. The lesions were classified by 4 criteria: the degree of cellular atypia, linear, circumferential and glandular extension. The patient's age and the presence or absence of residual tumor in the hysterectomy specimen were recorded. In about half of the cases the lesions were fairly well differentiated and were located at the squamocolumnar area without extension beyond 2 cervical quadrants and the superficial endocervical glands. The other half presented highly anaplastic and extensive in situ carcinomas. These patients were older and all 17 cases of residual tumor in this series occurred in this group. The most important factors in determining the presence of residual tumor are the degree of linear and circumferential extension. The grading of CIS on cone biopsy according to this method may effect a re‐evaluation of the indications for hysterectomy in which the cone biopsy itself may constitute final therapy.