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Morphologic changes induced in the lungs of hamsters and rats by external radiation (x‐rays): A study in experimental carcinogenesis
Author(s) -
de Villiers A. J.,
Gross Paul
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196610)19:10<1399::aid-cncr2820191011>3.0.co;2-x
Subject(s) - medicine , hamster , adenocarcinoma , cancer , lung , carcinogenesis , lung cancer , basal cell , pathology , nuclear medicine , mesocricetus
Pulmonary cancers in hamsters and rats were induced with external radiation (x‐rays). The induction and latent period of the pulmonary cancers observed in hamsters were reproducible. Invasive squamous cell carcinomata appeared in 5 (12%) of the 42 hamsters which died within the first 20 postirradiation weeks. In rats one squamous cell cancer and one adenocarcinoma were found in 32 animals which survived 12 to 24 months after irradiation. Pulmonary cancers were not found in hamsters later than 3 1/2 months postirradiation. This coincided with a predominance of mural stromal collagenization and the development of acellularity of alveolar walls. The method of producing lung cancer in hamsters and rats is suitable as an experimental model for the study of lung cancer because of the reproducibility and the control over experimental exposure factors. X‐rays were delivered to the chest region of the unanesthetized 8‐week‐old animals through a 2 cm diameter collimator and 4 portals varied through 90 degrees per day for 5 days. X‐rays were generated by a unit operated at 135 kv, 4 ma, 2.43 Al filtration and a T.S.D. of 16 cm. An average total dose of between 3,912 R and 4,094 R was delivered to the chest region of hamsters. Rats received an estimated 3,570 R.