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Cetrimide as an irrigant in wounds seeded with cancer
Author(s) -
Stephens Frederick O.,
Gibson Geoffrey R.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196609)19:9<1286::aid-cncr2820190915>3.0.co;2-j
Subject(s) - cetrimide , hydrogen peroxide , nitrogen mustard , medicine , cancer , nitrogen , surgery , biochemistry , chemistry , dentistry , organic chemistry , chemotherapy , chlorhexidine , cyclophosphamide
The incidence of local recurrence of tumor in operation wounds following surgery for malignant disease has resulted in a great number of physical and chemical agents being investigated to remove or destroy cells from operation wounds. Perhaps the most effective substance widely used is nitrogen mustard. In this study, the results of irrigation of experimental wounds seeded with cancer cells with hydrogen peroxide and the quarternary ammonium, cetrimide, have been compared with irrigation with nitrogen mustard. Hydrogen peroxide achieved greater success than nitrogen mustard in preventing tumor growth in the wounds but cetrimide proved to be more effective than either nitrogen mustard or hydrogen peroxide.