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Serum 5′‐nucleotidase in patients with tumor in the liver
Author(s) -
Smith K.,
Varon H. H.,
Race G. J.,
Paulson D. L.,
Urschel H. C.,
Mallams J. T.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196609)19:9<1281::aid-cncr2820190914>3.0.co;2-0
Subject(s) - 5' nucleotidase , alkaline phosphatase , medicine , nucleotidase , malignancy , enzyme , liver enzyme , gastroenterology , phosphatase , endocrinology , pathology , adenosine , chemistry , biochemistry
In 11 patients with a histological diagnosis of liver tumor, the 5′‐nucleotidase was elevated in each case. Only 6 of these patients showed an increase of the serum alkaline phosphatase, which was always of a smaller magnitude than the elevation of the 5′‐nucleotidase. In 6 patients with an unequivocal isotope liver scan for metastatic tumor without positive tissue diagnosis 2 patients showed elevations of both enzymes; 2 patients showed slight elevation of the 5′‐nucleotidase with no change in the alkaline phosphatase and 2 patients showed no change in either enzyme. These data suggest that the serum 5′‐nucleotidase shows a greater sensitivity in the detection of primary or metastatic hepatic malignancy in the anicteric patient than does the serum alkaline phosphatase. The authors believe that the apparent increased sensitivity is related to the greater specificity of this enzyme for hepatobiliary disease.