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Anaerobic glycolysis in normal and leukemic bone‐marrow leukocytes: Effect of methyl‐glyoxal‐bis‐guanylhydrazone dihydrochloride
Author(s) -
Kolmeier Karl H.,
Silverstein Murray N.,
Fleisher Gerard A.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196609)19:9<1195::aid-cncr2820190903>3.0.co;2-v
Subject(s) - bone marrow , medicine , anaerobic glycolysis , leukemia , glycolysis , anaerobic exercise , acute leukemia , metabolism , physiology
At the Mayo Clinic a study was made of the anaerobic glycolysis of leukocytes obtained from bone marrow of 8 normal individuals and 16 patients with acute leukemias plus leukocytes from the peripheral blood of 8 normal donors. Normal leukocytes from bone marrow had significantly lower glycolytic rates than those from peripheral blood. Bone‐marrow leukocytes from patients with untreated myelomonocytic leukemia had significantly greater rates than normal bone‐marrow leukocytes. The inhibitory effect of methyl‐glyoxal‐bis‐guanyl‐hydrazone dihydrochloride on the anaerobic glycolysis of leukocytes appeared to be similar whether the cells were obtained from normal individuals or from patients with acute leukemia.