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Relationship of podophyllin to carcinogenesis. A comparison of cytologic and histologic changes induced by podophyllin in the mouse cervix with those induced by 3,4 benzpyrene
Author(s) -
Garret Marta
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196607)19:7<947::aid-cncr2820190708>3.0.co;2-0
Subject(s) - podophyllin , dysplasia , carcinogen , medicine , cervix , carcinoma in situ , pathology , carcinoma , dermatology , biology , cancer , genetics
Carcinogenic potentialities of podophyllin were investigated by long‐term application of 20% podophyllin suspension in mineral oil to mouse cervix of C 3 H mice. Cytologic and histologic changes induced by podophyllin were compared with changes induced by a proven carcinogen (3,4 benzpyrene). Some forms of podophyllin‐induced dysplasia resembled benzpyrene‐induced dysplasia. The classical pattern of human carcinoma in situ was seen only in the presence of invasive carcinoma induced by benzpyrene. Variety of lesions resembling radiation effect were induced by podophyllin only. No invasive lesion was encountered with 340 paintings of the cervix with 20% podophyllin in mineral oil. Invasive squamous carcinomas were found after a thread saturated with a 20% podophyllin suspension in mineral oil was inserted in the endocervical canal.