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Histochemical study of the enzymatic activity of human neoplasms. II. Histogenesis of renal cell carcinoma
Author(s) -
Braunstein Herbert,
Adelman James U.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196607)19:7<935::aid-cncr2820190706>3.0.co;2-d
Subject(s) - alkaline phosphatase , staining , histogenesis , acid phosphatase , phosphatase , stain , enzyme , renal cell carcinoma , biochemistry , chemistry , pathology , biology , immunohistochemistry , medicine
Of 12 renal cell carcinomas studied, 7 stained positively for alkaline phosphatase; 5 did not. Acid phosphatase and nonspecific exterase activity, glycogen content, lipid staining and histologic pattern bore no constant relationship to alkaline phosphatase staining. There was excellent correlation of alkaline phosphatase staining with amino‐peptidase activity and many also manifested glucose‐6‐phosphatase and 5′‐nucleotidase. The authors conclude that those renal cell carcinomas with alkaline phosphatase activity are of proximal tubular origin while those that do not stain originate in other tubular segments.