Premium
Chromosome abnormalities in human cancer. Report of a patient with chronic myelocytic leukemia and his nonleukemic monozygotic twin
Author(s) -
Jacobs Edwin M.,
Luce James K.,
Cailleau Relda
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196606)19:6<869::aid-cncr2820190620>3.0.co;2-o
Subject(s) - myelocytic leukemia , chromosome , medicine , bone marrow , karyotype , pathology , leukemia , genetics , biology , gene
Chromosome studies were made on a 31‐year‐old man (H. vG.) with chronic myelocytic leukemia and his normal identical twin (L. vG.). Identical blood typing factors (17 tested) and similar fingerprint analyses warrant the conclusion that the twins are monozygous. Characteristic Ph 1 chromosomes were found in blood and bone marrow from H.vG. before and after treatment with the colchicine analog, trimethyl colchicinic acid. During therapy the white blood count decreased from nearly 400,000/mm 3 to less than 10,000/mm 3 . By contrast, analyses of blood and fresh bone marrow from L.vG. were consistently negative for the Ph 1 chromosome. These results reinforce the postulate that the Ph 1 chromosome is an acquired abnormality rather than a hereditary defect of the chromosome.