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Clinical value of preoperative cancer chemotherapy as an index to the changes in tissue catalase activity
Author(s) -
Fujimoto Shigeru
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196606)19:6<844::aid-cncr2820190615>3.0.co;2-r
Subject(s) - medicine , catalase , cancer , chemotherapy , stomach , metastasis , oncology , lymph node , stomach cancer , oxidative stress
The effect of preoperative cancer chemotherapy on tissue catalase levels in 25 patients with gastric cancer has been studied. In the non‐neoplastic diseases studied elevated tissue catalase levels are shown. Preoperative cancer chemotherapy resulted in a significant increase in liver and metastatic lymph node catalase levels. There was a marked lowering of the hepatic catalase level in patients with either unresectable stomach cancer or liver metastasis. Preoperative cancer chemotherapy has not made it necessary to postpone operation because of its side effects.