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Coexistent lymphosarcoma and chronic granulocytic leukemia
Author(s) -
Wilson B. David,
Vanslyck Ellis J.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196606)19:6<809::aid-cncr2820190610>3.0.co;2-v
Subject(s) - medicine , chronic granulocytic leukemia , pathology , bone marrow , peripheral blood , lymph node biopsy , chronic lymphocytic leukemia , lymph node , leukemia , biopsy , stain , immunology , staining
The coexistence of lymphosarcoma and leukemias of lymphocytic origin is well established but that of lymphosarcoma and leukemia of granulocytic origin is very rare. This paper reports the case of a 54‐year‐old caucasian male who had lymphosarcoma of the cervical and mediastinal lymph nodes proven by biopsy and treated by irradiation. Two years after diagnosis the patient was found to have chronic granulocytic leukemia. This diagnosis was substantiated by typical peripheral blood and bone marrow findings and characteristic leucocyte alkaline phosphatase stain. The Ph 1 chromosome was not found in marrow or peripheral blood. Rebiopsy of a peripheral lymph node reaffirmed the continuing presence of lymphocytic lymphosarcoma. Both diseases still were present concurrently at the time of reporting 20 months later. Although the theoretical aspect of joining these 2 hematological neoplasms together as a mutation from pre‐existing lymphosarcoma to leukemic granulocytic cells is intriguing, the authors believe that these are 2 separate entities appearing concurrently.