Premium
Radioautography of in vitro labeled tumor cells in postoperative wound drainage
Author(s) -
Sako Kumao,
Marchetta Frank C.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196605)19:5<735::aid-cncr2820190520>3.0.co;2-c
Subject(s) - medicine , in vitro , wound healing , surgery , drainage , thymidine , tumor cells , head and neck , pathology , cancer research , biology , biochemistry , ecology
Wound drainage fluid from 23 patients who had undergone curative radical resections for cancers of the head and neck region were collected over a 72‐hour postoperative period. Five of these patients had wound‐drainage fluid containing tumor cells. By radioautography of in vitro incorporated tritiated thymidine, tumor cells in 2 of these specimens were found to be synthesizing DNA. The demonstration of labeling these cells offers additional evidence of the viability of some of the tumor cells which can be found in wound‐drainage fluid following curative resections.