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Cholinesterase and tyrosinase activity in malignant melanoma
Author(s) -
Mishima Yutaka
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196605)19:5<665::aid-cncr2820190510>3.0.co;2-d
Subject(s) - melanosome , tyrosinase , melanoma , medicine , cholinesterase , melanosis , melanin , cytoplasm , pathology , cancer research , dermatology , enzyme , biology , pharmacology , biochemistry
A series of human amelanotic and melanotic melanomas derived from both junction nevus and Dubreuilh's precancerous melanosis has been studied to investigate further the physiologic and cytopathogenic significance of cholinesterase in relation to the tyrosinase activity of these tumors. Cholinesterase activity has been found to be sharply localized in malignant melanoma of primary as well as metastatic lesions of the skin and viscera. It is evident that cholinesterase activity can exist concomitantly with tyrosinase activity in the cytoplasm of melanosome synthesizing melanoma cells.