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Efficiency of iodized suture in prevention of suture transferral of malignant tumors
Author(s) -
Keller James W.,
Kelley Henry G.,
Kinsey David L.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196604)19:4<549::aid-cncr2820190413>3.0.co;2-4
Subject(s) - fibrous joint , medicine , surgery
In inbred DBA/2J mice with CaD2 mammary carcinoma tumor was transferred in 70 to 80% of all attempts by passing silk or catgut suture through a donor tumor then into a recipient animal. However, the frequency of growth was reduced to 25% with iodinated suture. With the S‐91 melanoma use of silk or catgut resulted in 20 to 25% positive transferrals; this was reduced to 10% with iodine‐treated suture. In both tumor systems iodinated suture caused a delay in tumor growth and a prolongation of life in those animals in which tumor grew. There were no toxic reactions to the iodinated suture. Iodine‐treated suture should be superior to other suture materials in preventing suture transferral of tumor in clinical trials.