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Bronchogenic carcinoma simulating hyperparathyroidism
Author(s) -
Turkington Roger W.,
Goldman Jack K.,
Ruffner B. W.,
Dobson John L.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196603)19:3<406::aid-cncr2820190314>3.0.co;2-o
Subject(s) - medicine , primary hyperparathyroidism , calcium , carcinoma , bronchogenic carcinoma , parathyroid carcinoma , hyperparathyroidism , urology , lung , gastroenterology , pathology
Four cases are reported of hypercalcemia and bronchogenic carcinoma without demonstrable bone metastases. Studies on serum calcium and phosphorous, phosphate clearance, urinary calcium, rapid calcium infusion test, and ultrafiltrable serum calcium indicated changes characteristic of primary hyperparathyroidism. Surgical extirpation of the lung carcinoma in 2 cases reverted these parameters to normal while x‐radiation of the other 2 carcinomas transiently returned serum calcium and phosphorus to normal levels. Adrenocorticoid therapy caused partial suppression of hypercalcemia in 2 instances. All 4 tumors were squamous cell carcinomas. It is concluded that the single criterion for establishing that hypercalcemia is secondary to a humorally active nonmetastatic tumor is the reduction of serum calcium in response to x‐radiation or surgical removal of the tumor.