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Biochemical studies of human tumors. II. In vitro estimation of individual tumor sensitivity to anticancer agents
Author(s) -
Bickis I. J.,
Henderson I. W. D.,
Quastel J. H.
Publication year - 1966
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(196601)19:1<103::aid-cncr2820190111>3.0.co;2-s
Subject(s) - in vitro , in vivo , medicine , drug , tumor cells , pharmacology , anticancer drug , cancer research , biology , biochemistry , genetics
Slices from fresh human tumor specimens were incubated in presence of radioactive tracers and a spectrum of anticancer drugs. The drug effects were estimated from the changed rates of tracer incorporation into DNA, RNA, and protein. In a group of some 40 tumors analyzed the response of each tumor was highly individualistic although the observed effects were consistent with the known modes of action of respective drugs. Nevertheless, they could be classified broadly as: 1) tumors resistant to all drugs, 2) tumors sensitive to most drugs and 3) tumors selectively sensitive to one or few drugs and resistant against others. Case histories are given, which demonstrate the generally good correlation between in vitro and in vivo tumor sensitivities.