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Receptors coupling to G proteins: Is there a signal behind the sequence?
Author(s) -
Horn Florence,
van der Wenden Eleonora M.,
Oliveira Laerte,
IJzerman Adriaan P.,
Vriend Gerrit
Publication year - 2000
Publication title -
proteins: structure, function, and bioinformatics
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.699
H-Index - 191
eISSN - 1097-0134
pISSN - 0887-3585
DOI - 10.1002/1097-0134(20001201)41:4<448::aid-prot30>3.0.co;2-c
Subject(s) - heterotrimeric g protein , receptor , g protein coupled receptor , g protein , signal (programming language) , sequence (biology) , biology , signal transduction , coupling (piping) , chemistry , microbiology and biotechnology , biophysics , biochemistry , computer science , materials science , programming language , metallurgy
Upon the binding of their ligands, G protein‐coupled receptors couple to the heterotrimeric G proteins to transduce a signal. One receptor family may couple to a single G protein subtype and another family to several ones. Is there a signal in the receptor sequence that can give an indication of the G protein subtype selectivity? We used a sequence analysis method on biogenic amine and adenosine receptors and concluded that a weak signal can be detected in receptor families where specialization for coupling to a given G protein occurred during a recent divergent evolutionary process. Proteins 2000;41:448–459. © 2000 Wiley‐Liss, Inc.