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Novel blends of poly[bis(glycine ethyl ester) phosphazene] and polyesters or polyanhydrides: compatibility and degradation characteristics in vitro
Author(s) -
Qiu L Y,
Zhu K J
Publication year - 2000
Publication title -
polymer international
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.592
H-Index - 105
eISSN - 1097-0126
pISSN - 0959-8103
DOI - 10.1002/1097-0126(200011)49:11<1283::aid-pi471>3.0.co;2-d
Subject(s) - sebacic acid , polymer chemistry , plga , polyester , phosphazene , materials science , chemistry , polymer blend , solvent , nuclear chemistry , copolymer , polymer , organic chemistry , in vitro , biochemistry
Poly[bis(glycine ethyl ester)phosphazene] (PGP) was blended with poly( D , L ‐lactide) (PLA), poly( D , L ‐lactide‐ co ‐glycolide) (80:20 by mole) (PLGA), poly(sebacic anhydride) (PSA) and poly(sebacic anhydride‐ co ‐trimellitylimidoglycine)‐ block ‐poly(ethylene glycol) (30:50:20 by mole) (PSTP) in various ratios using a solvent‐mixing technique. The compatibility of these blends has been evaluated by DSC, FTIR and phase contrast microscopy. The results indicated that PGP is completely incompatible with PLA, but partially compatible with PLGA and PSTP, which may be attributed to a hydrogen bonding effect. Degradation experiments have been conducted in distilled water at 37 °C and show that the blend degradation rate can be regulated by adjusting the PLGA or PSTP content of the blends. PGP/PLGA (70:30 by wt) slabs took 120 days to disappear completely, while PGP/PSTP (70:30 by wt) slabs needed only 20 days. These findings suggest that blends of PGP and PLGA or PSTP may be used as matrices for drug controlled release and for other potential biomedical applications. © 2000 Society of Chemical Industry