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Renal Doppler sonographic and histologic findings in post‐transplant primary cytomegalovirus disease
Author(s) -
Salgado Octavio J.,
Henríquez Carlos,
Rosales Beatriz,
Martín María G.,
García Rafael,
RodríguezIturbe Bernardo
Publication year - 2000
Publication title -
journal of clinical ultrasound
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.272
H-Index - 61
eISSN - 1097-0096
pISSN - 0091-2751
DOI - 10.1002/1097-0096(200010)28:8<430::aid-jcu9>3.0.co;2-y
Subject(s) - medicine , cytomegalovirus , transplantation , cytomegalovirus infection , biopsy , betaherpesvirinae , kidney transplantation , kidney , cadaveric spasm , renal transplant , surgery , pathology , viral disease , herpesviridae , immunology , virus , human cytomegalovirus
Cytomegalovirus (CMV) infections frequently develop in renal transplant patients. The transplanted kidney may be not only the source of infection but also the target for it. We report a case of primary CMV infection in a seronegative patient who received a graft from a seropositive cadaveric donor. The onset of CMV was clinically apparent on post‐transplant day 22. Interestingly, soon after transplantation, the patient developed a long‐lasting graft dysfunction episode for which diffuse endothelial‐cell swelling was the most relevant finding at biopsy. On sonography, renal graft vascular impedance deteriorated and improved repeatedly during the follow‐up period. We postulate that the patient had CMV‐induced immunogenic‐mediated endothelial‐cell injury. © 2000 John Wiley & Sons, Inc. J Clin Ultrasound 28:430–434, 2000.