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Prostatic intraepithelial neoplasia: Animal models 2000
Author(s) -
Bostwick David G.,
Ramnani Dharam,
Qian Junqi
Publication year - 2000
Publication title -
the prostate
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.295
H-Index - 123
eISSN - 1097-0045
pISSN - 0270-4137
DOI - 10.1002/1097-0045(20000601)43:4<286::aid-pros8>3.0.co;2-0
Subject(s) - intraepithelial neoplasia , prostate cancer , animal model , prostate , medicine , cancer , high grade prostatic intraepithelial neoplasia , pathology , oncology
Numerous animal models of preinvasive prostate cancer have been described in the past decade. Differences among models account for their variable applicability for answering specific research questions. The dog is the only known nonhuman spontaneous animal model of prostate cancer, but numerous transgenic and therapy‐induced models have been generated in mice and rats. This report summarizes existing models of prostatic intraepithelial neoplasia and their relevance for the study of human prostate cancer. Prostate 43:286–294, 2000. © 2000 Wiley‐Liss, Inc.