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Transport of nutrients across the choroid plexus
Author(s) -
Segal Malcolm B.
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/1097-0029(20010101)52:1<38::aid-jemt6>3.0.co;2-j
Subject(s) - choroid plexus , choroid , cerebrospinal fluid , transthyretin , efflux , biology , anatomy , chemistry , microbiology and biotechnology , biochemistry , retina , endocrinology , neuroscience , central nervous system
A brief outline is given first of the early history of the ventricles and the strange ideas of their functions from Galen to the enlightenment of the Renaissance with the work of Versalius. This is followed by a description of the histology of the choroid plexuses (CP) and discussion on the functions of the choroid plexus and on the composition of cerebrospinal fluid (CSF). The methods of measuring the rate of secretion of CSF will be outlined and the possible nutritive functions of the choroid plexuses will be considered. The role of the choroid plexuses in the control of the concentration of glucose and amino acids in CSF will be compared with data from in vitro experiments to that from the isolated vascularly perfused choroid plexuses. The handling of peptides and proteins by the CP and the synthesis of these molecules by this tissue is then discussed and the effects of lead on the synthesis of transthyretin by this tissue. Finally, reference will be made to the extensive neuro‐endocrine role of the CP and efflux systems across the tissue for lipid soluble molecules. Microsc. Res. Tech. 52:38–48, 2001. © 2001 Wiley‐Liss, Inc.