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Peroxisome biogenesis and degradation in yeast: A structure/function analysis
Author(s) -
Veenhuis Marten,
Salomons Florian A.,
Van Der Klei Ida J.
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/1097-0029(20001215)51:6<584::aid-jemt8>3.0.co;2-w
Subject(s) - peroxisome , biogenesis , complementation , yeast , biology , function (biology) , biochemistry , gene , organelle , mutant , microbiology and biotechnology
In yeast, peroxisomes are the site of specific catabolic pathways that characteristically include hydrogen peroxide producing oxidases and catalase. During the last 10 years, much progress has been made in unravelling the molecular mechanisms involved in the biogenesis of this organelle. At present, 23 different genes ( PEX genes) have been identified that are involved in different aspects of peroxisome biogenesis (e.g., proliferation, formation of the peroxisomal membrane, import of matrix proteins). The principles of peroxisome degradation are still much less understood. Recently, the first yeast mutants affected in this process have become available and used to clone corresponding genes by functional complementation. In this paper, an overview is presented of the research on yeast peroxisomes, focusing on recent achievements in the molecular aspects of peroxisome development, function, and turnover. Microsc. Res. Tech. 51:584–600, 2000. © 2000 Wiley‐Liss, Inc.