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Transcriptional regulation of laminin gene expression
Author(s) -
Aberdam Daniel,
Virolle Thierry,
SimonAssmann Patricia
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/1097-0029(20001101)51:3<228::aid-jemt3>3.0.co;2-9
Subject(s) - laminin , gene isoform , basement membrane , glycoprotein , gene , biology , gene expression , microbiology and biotechnology , transcription (linguistics) , regulation of gene expression , genetics , extracellular matrix , linguistics , philosophy
Laminins are the most abundant structural non‐collagenous glycoproteins ubiquitously present in basement membranes. They are multidomain molecules consisting of of alpha, beta, and gamma chains. Although the precise functional differences between the laminin variants are not well understood, the diversity of laminin isoforms may reflect the formation of distinct basement membranes. The laminins display a remarkable restricted expression profile, suggesting a fine regulation of their genes. In this review, we focus on the most recent developments of laminin biology, centering on transcriptional and posttranscriptional controls. We discuss only those laminin chains whose gene organization and promoter elements have been characterized and proved to be functional. When possible, we correlate the effects of growth factors, cytokines, retinoids, and transcription factors on laminin gene expression with the identity of cis‐acting elements in their genomic control regions. Microsc. Res. Tech. 51:228–237, 2000. © 2000 Wiley‐Liss, Inc.