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Adhesion complexes implicated in intestinal epithelial cell‐matrix interactions
Author(s) -
Stutzmann Jeanne,
BellissentWaydelich Anne,
Fontao Lionel,
Launay JeanFrançois,
SimonAssmann Patricia
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/1097-0029(20001015)51:2<179::aid-jemt9>3.0.co;2-4
Subject(s) - extracellular matrix , integrin , microbiology and biotechnology , cell adhesion , hemidesmosome , adhesion , cell adhesion molecule , transmembrane protein , biology , matrix (chemical analysis) , cell , chemistry , basement membrane , biochemistry , receptor , organic chemistry , chromatography
This article review summarizes data on cell‐substratum adhesion complexes involved in the regulation of cellular functions in the intestine. We first focus on the molecular composition of the two main adhesion structures—the β1 integrin‐adhesion complex and the hemidesmosome—found in vivo and in two human intestinal cell lines. We also report the key findings on the cellular behavior and response to the extracellular matrix that involve integrins, the main transmembrane anchors of these complexes. How the dynamics of cell/extracellular matrix interactions contribute to cell migration, proliferation, differentiation, and tumorigenicity is discussed in the light of the data provided by the human intestinal cells. Microsc. Res. Tech. 51:179–190, 2000. © 2000 Wiley‐Liss, Inc.