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Very low density lipoprotein receptor in Alzheimer disease
Author(s) -
Helbecque Nicole,
Amouyel Philippe
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/1097-0029(20000815)50:4<273::aid-jemt4>3.0.co;2-0
Subject(s) - ldl receptor , apolipoprotein e , receptor , very low density lipoprotein , lipoprotein , apolipoprotein b , gene isoform , lrp1b , biology , alzheimer's disease , low density lipoprotein receptor related protein 8 , endocrinology , genetics , medicine , disease , cholesterol , gene
The apolipoprotein (APO) E4 isoform is associated with an accelerated rate of Alzheimer disease (AD) expression in sporadic as well as late‐onset familial forms of the disease but the precise mechanism is unknown. In an attempt to approach the possible mechanisms involved, APOE receptors have been studied. They all belong to the low density lipoprotein (LDL) receptor family and share the same structural motifs. Some of them are preferentially expressed in the brain such as the LDL receptor related protein, the apolipoprotein E receptor 2, and the very low density lipoprotein (VLDL) receptor. These receptors have been suspected to be involved in Alzheimer disease at various levels. Among them, the VLDL receptor was extensively explored. Although genetic studies conducted on a polymorphism in the promoter of the VLDL receptor in Japanese and Caucasian populations gave divergent results, this does not exclude a possible involvement of the VLDL receptor in AD. Microsc. Res. Tech. 50:273–277, 2000. © 2000 Wiley‐Liss, Inc.