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Neurotrophins and development of the rod pathway
Author(s) -
Rickman Dennis W.
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/1097-0029(20000715)50:2<124::aid-jemt4>3.0.co;2-k
Subject(s) - synaptogenesis , neuroscience , retina , biology , neurotrophin , neurogenesis , neurochemical , retinal , muller glia , interneuron , neurotrophic factors , scotopic vision , gliogenesis , microbiology and biotechnology , stem cell , inhibitory postsynaptic potential , genetics , neural stem cell , progenitor cell , biochemistry , receptor
The rodent retina is a particularly attractive model for the study of neuronal developmental processes since considerable neurogenesis, cellular migration, phenotypic differentiation of retinal cell types and synaptogenesis occurs postnatally. In addition, the retina is readily accessible to surgical intervention, pharmacological manipulation, and local suppression of gene expression—tools that can be utilized to study mechanisms underlying the development of retinal neurons and their interconnections that form distinct functional circuits. Here, I review our studies describing the ontogeny of a specific retinal interneuron, the AII amacrine cell, an integral element in the rod (scotopic) pathway. Specifically, we used a number of approaches to examine the potential role of neurotrophic factors on the morphological and neurochemical differentiation of the AII. Microsc. Res. Tech. 50:124–129, 2000. © 2000 Wiley‐Liss, Inc.