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Neuronal nitric oxide synthase immunoreactive neurons in the mammalian retina
Author(s) -
Kim InBeom,
Oh SuJa,
Chun MyungHoon
Publication year - 2000
Publication title -
microscopy research and technique
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.536
H-Index - 118
eISSN - 1097-0029
pISSN - 1059-910X
DOI - 10.1002/1097-0029(20000715)50:2<112::aid-jemt3>3.0.co;2-s
Subject(s) - nitric oxide synthase , neuronal nitric oxide synthase , retina , nitric oxide , neuroscience , atp synthase , microbiology and biotechnology , chemistry , biology , biochemistry , enzyme , endocrinology
The development of immunocytochemistry has led to a better understanding of synaptic transmission carried out by neuroactive substances in the mammalian brain, including the retina. In the mammalian retina, nitric oxide (NO) is widely accepted as a neuromodulator. Histochemistry based on NADPH‐d and immunocytochemistry based on nitric oxide synthase (NOS) have been used to identify the presence of nitric oxide in the mammalian retina. Certain types of amacrine cells and a class of displaced amacrine cells have been labeled consistently in all mammalian retinae studied to date. Other cell types showing NADPH‐d reactivity or NOS immunoreactivity varied between species. NADPH‐d reactive or NOS immunoreactive amacrine cells may serve as a source of NO for amacrine, bipolar, and ganglion cells in the inner retina, whereas interplexiform cells, bipolar cells, and horizontal cells may serve as a source of NO for the outer retina of mammals. Microsc. Res. Tech. 50:112–123, 2000. © 2000 Wiley‐Liss, Inc.