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Inflammation in human skin: a model to study chemokine‐mediated leukocyte migration in vivo
Author(s) -
Gillitzer R.
Publication year - 2001
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/1096-9896(200108)194:4<393::aid-path907>3.0.co;2-7
Subject(s) - cxcr3 , chemokine , cxcl9 , inflammation , cxcl10 , immunology , cxcl2 , dermis , chemokine receptor , cxc chemokine receptors , in vivo , cc chemokine receptors , biology , cxcl16 , microbiology and biotechnology , medicine , pathology
The structure of the skin, with the preferential unidirectional migration of inflammatory cells from blood vessels to the dermis and eventually to the epidermis, its accessibility for biopsies and local manipulations, and the clear definition of various inflammatory disorders, makes it an ideal in vivo model organ to study mechanisms of leukocyte recruitment during inflammation. A report in this issue of the Journal studied selected inflammatory skin disorders with different well‐characterized inflammatory profiles to study the important role of the T‐cell‐attractant chemokines Mig (CXCL9) and IP‐10 (CXCL10). These chemokines are highly expressed and participate in the recruitment of CXC receptor 3 (CXCR3)+ effector T‐cells and their migration to the site of inflammatory challenge. This indicates that the chemokines Mig and IP‐10 are important mediators for T‐cell dominated inflammatory reactions in the skin. Copyright © 2001 John Wiley & Sons, Ltd.