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Serrated route to colorectal cancer: back street or super highway?
Author(s) -
Jass Jeremy R.
Publication year - 2001
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/1096-9896(200103)193:3<283::aid-path799>3.0.co;2-9
Subject(s) - microsatellite instability , colorectal cancer , cancer research , hyperplastic polyp , chromosome instability , chromosome , mutation , biology , cancer , genome instability , genetics , aberrant crypt foci , dna , dna damage , microsatellite , gene , colonic disease , allele , colonoscopy
Morphological and molecular studies are beginning to distinguish separate evolutionary pathways for colorectal cancer. The serrated pathway encompassing hyperplastic aberrant crypt foci, hyperplastic polyps, mixed polyps, and serrated adenoma is increasingly being linked with genetic alterations, including DNA methylation, DNA microsatellite instability, K‐ras mutation, and loss of chromosome 1p. The importance of the serrated pathway has been underestimated in terms of its frequency and potential for rapid progression. Copyright © 2001 John Wiley & Sons, Ltd.