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Clinicopathologic evaluation of CDw75 antigen expression in patients with gastric carcinoma
Author(s) -
Özlem Elpek Gülsüm,
Gelen Tekinalp,
Karpuzoǧlu Gülten,
Karpuzoǧlu Tuncer,
Keles Nuran
Publication year - 2001
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/1096-9896(200102)193:2<169::aid-path756>3.0.co;2-p
Subject(s) - immunohistochemistry , antigen , pathology , cancer , staining , medicine , carcinoma , stage (stratigraphy) , biology , immunology , paleontology
Situated on mature B lymphocytes, CDw75 antigen is a sialylated carbohydrate epitope generated by the enzyme β‐galactosyl α‐2,6‐sialyltransferase. Although CDw75 antigen expression was found to be correlated with aggressive behaviour of tumour cells in gastric adenocarcinomas, its prognostic role still remains unknown. The objective of this study was to determine the value of CDw75 antigen expression as a marker of the metastatic potential and prognosis of gastric adenocarcinomas. CDw75 antigen expression was evaluated immunohistochemically in 64 tumours and their nodal metastases. The correlation was analysed between CDw75 antigen expression and selected clinicopathological variables, including surrival. Positive staining was detected in 31 cases. Non‐neoplastic gastric mucosa was consistently negative. CDw75 expression was correlated with larger tumour size ( p <0.006), infiltrative growth pattern ( p <0.044), advanced stage ( p <0.0006), and positive lymph nodes ( p <0.0003).The overall survival rate of patients with CDw75 expression was 28%, which was significantly worse than that of patients without CDw75 expression (53%) ( p <0.0005). Multivariate analysis showed that CDw75 expression was an independent prognostic indicator, together with the growth pattern of the tumour. These results indicate that immunohistochemical detection of CDw75 antigen expression may be a good indicator of metastatic potential and of prognosis in patients with gastric carcinomas. Copyright © 2000 John Wiley & Sons, Ltd.