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Designing a molecular analysis of clonality in tumours
Author(s) -
DiazCano Salvador J.
Publication year - 2000
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/1096-9896(200008)191:4<343::aid-path617>3.0.co;2-y
Subject(s) - chromosome analysis , computational biology , transformation (genetics) , biology , interpretation (philosophy) , chromosome , subject (documents) , genetics , pathology , medicine , computer science , karyotype , gene , programming language , library science
Clonality analysis is used to test malignant transformation and tumour progression. X‐chromosome linked clonality assays have been employed for this purpose, but are subject to certain technical limitations. This paper reviews the issues involved and the controls that are necessary to ensure valid interpretation of such analyses.