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Human papillomavirus variants and squamous neoplasia of the cervix
Author(s) -
Giannoudis Athina,
Simon Herrington C.
Publication year - 2001
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/1096-9896(2000)9999:9999<::aid-path809>3.0.co;2-c
Subject(s) - cervix , cervical intraepithelial neoplasia , human papillomavirus , koilocyte , intraepithelial neoplasia , etiology , risk factor , hpv infection , papillomaviridae , biology , typing , virology , cervical cancer , medicine , pathology , genetics , cancer , prostate
Human papillomaviruses (HPVs) play a central role in the aetiology of cervical neoplasia. However, only a small proportion of cervical intraepithelial lesions infected with high‐risk HPVs will progress to invasive cervical carcinoma, which indicates the involvement of additional factors. An important emerging viral factor is naturally occurring intratypic sequence variation. Such variation has been used to study the geographical spread of HPVs, but there is increasing evidence that it may be important in determining the risk of development of neoplastic disease. The collected data indicate that different HPV variants have altered biochemical and biological properties and represent an additional risk factor in the development of squamous intraepithelial lesions and invasive carcinoma of the cervix. This may be relevant not only to the biology of HPV infection and its association with squamous neoplasia, but also to the use of HPV typing in clinical practice. Copyright © 2000 John Wiley & Sons, Ltd.