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Significantly different bcl‐2 expression profiles in gastric and non‐gastric primary extranodal high‐grade B‐cell lymphomas
Author(s) -
Cogliatti Sergio B.,
Griesser Henrik,
Peng Huaizheng,
Du MingQing,
Isaacson Peter G.,
Zimmermann Dieter R.,
Maibach Rudolf C.,
Schmid Ulrico
Publication year - 2000
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/1096-9896(2000)9999:9999<::aid-path733>3.0.co;2-u
Subject(s) - gastric lymphoma , lymphoma , stomach , pathology , biology , chromosomal translocation , immunohistochemistry , phenotype , cancer research , medicine , gene , genetics
Fifty‐five cases of primary extranodal high‐grade B‐cell non‐Hodgkin's lymphoma were investigated for bcl‐2 and p53 protein expression as well as for t(14;18) translocations and p53 mutations. Phenotypic and genotypic profiles were compared between tumours of gastric (27 cases) and non‐gastric (28 cases) origin. bcl‐2 protein expression was significantly lower in gastric (11/27) than in non‐gastric (28/28) lymphomas ( p <0.0001), while nuclear p53 protein expression did not differ significantly between these two groups. In the stomach, there were no significant differences in either bcl‐2 or p53 expression profiles between high‐grade lymphomas with ( n =14) and without ( n =13) evidence of a low‐grade component of MALT type. However, secondary high‐grade lymphomas showed a significant down‐regulation of bcl‐2 protein ( p <0.0001) and, conversely, an up‐regulation of p53 protein ( p <0.0001) as compared with their low‐grade tumour components. In extranodal high‐grade B‐cell lymphomas, bcl‐2 protein expression was not associated with t(14;18) translocation. Only one gastric lymphoma had a p53 point mutation with potential alteration of the amino acid sequence. These findings indicate that primary gastric high‐grade B‐cell lymphomas are immunohistologically distinct from primary extranodal high‐grade B‐cell lymphomas of an origin other than in the stomach. Copyright © 2000 John Wiley & Sons, Ltd.