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Reduced CD44 standard expression is associated with tumour recurrence and unfavourable outcome in differentiated thyroid carcinoma
Author(s) -
Böhm Jan P.,
Niskanen Leo K.,
Pirinen Risto T.,
Kiraly Kari,
Kellokoski Jari K.,
Moisio Kaisa I.,
Eskelinen Matti J.,
Tulla Harri E.,
Hollmen Sinikka,
Alhava Esko M.,
Kosma VeliMatti
Publication year - 2000
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/1096-9896(2000)9999:9999<::aid-path711>3.0.co;2-1
Subject(s) - medicine , cd44 , univariate analysis , stage (stratigraphy) , thyroid carcinoma , carcinoma , pathology , cancer , immunohistochemistry , oncology , thyroid , gastroenterology , multivariate analysis , biology , cell , paleontology , genetics
CD44 was detected with an antibody recognizing all forms of CD44 (CD44 standard) and others specific for its v3 and v6 variant isoforms; their prognostic value was evaluated in 213 patients with differentiated thyroid carcinoma (DTC). The staining patterns of CD44 standard (s) and CD44v6 in tumour tissue were quite similar, 176 cases (83%) being highly positive for CD44s and 153 cases (72%) for CD44v6. Only 18 (9%) tumours showed high expression of CD44v3. Papillary carcinomas were significantly more often high expressors of CD44s and CD44v6 than follicular carcinomas ( p <0.001 for both). Age older than 60 years, distant metastases, and advanced pTNM stage were related to loss of expression of CD44s ( p <0.001, p =0.021, and p =0.003, respectively). Tumour recurrence and cancer‐related mortality were related to the reduced level of CD44s ( p =0.049 and p =0.042). CD44v3 did not associate with any of the clinicopathological factors. In univariate analysis, CD44s was the only significant prognostic factor for disease‐free survival ( p =0.0488). In multivariate analysis, CD44s and thyroglobulin level were significant prognostic factors for disease‐free survival ( p =0.040 and p <0.001, respectively). The reduced level of CD44s in DTC patients seems to be an independent prognostic factor for unfavourable disease outcome. Copyright © 2000 John Wiley & Sons, Ltd.