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A light and electron microscopic study of osteogenesis imperfecta bone samples, with reference to collagen chemistry and clinical phenotype
Author(s) -
Sarathchandra P.,
Pope F. M.,
Kayser M. V.,
Ali S. Y.
Publication year - 2000
Publication title -
the journal of pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.964
H-Index - 184
eISSN - 1096-9896
pISSN - 0022-3417
DOI - 10.1002/1096-9896(2000)9999:9999<::aid-path704>3.0.co;2-u
Subject(s) - osteogenesis imperfecta , osteoid , ultrastructure , type i collagen , pathology , chemistry , collagen fibril , fibril , collagen, type i, alpha 1 , electron microscope , bone histomorphometry , anatomy , trabecular bone , biology , medicine , osteoporosis , extracellular matrix , biochemistry , physics , optics
A detailed morphological study was carried out using light and electron microscopy on 36 bone specimens from patients suffering from osteogenesis imperfecta (OI) and 20 age‐ and site‐matched control bone specimens. The findings were grouped into the clinical types of OI according to the Sillence classification. The morphological and ultrastructural alterations observed in OI bone correlate well with clinical severity. Thus, OI type I, the mildest type, showed the least abnormalities in bone ultrastructure. OI type IV closely resembled type I, with only minor abnormalities in the bone cells and osteoid. OI type III showed abnormalities in the structure and distribution of osteoid collagen fibrils, whilst OI type II, the lethal form, revealed many varied abnormalities such as thin cortical bone, sparse trabecular bone, increased numbers of osteoclasts and osteocytes, thin osteoid with thin collagen fibrils, and patchy mineralization. Copyright © 2000 John Wiley & Sons, Ltd.