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Separation of o ‐, m ‐ and p ‐phthalic acids by high‐field asymmetric waveform ion mobility spectrometry (FAIMS) using mixed carrier gases
Author(s) -
Barnett David A.,
Purves Randy W.,
Ells Barbara,
Guevremont Roger
Publication year - 2000
Publication title -
journal of mass spectrometry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.475
H-Index - 121
eISSN - 1096-9888
pISSN - 1076-5174
DOI - 10.1002/1096-9888(200008)35:8<976::aid-jms25>3.0.co;2-q
Subject(s) - chemistry , ion mobility spectrometry , phthalic acid , mass spectrometry , ion , electrospray ionization , fragmentation (computing) , analytical chemistry (journal) , electrospray , chromatography , adduct , organic chemistry , computer science , operating system
Baseline separation of the three isomers of phthalic acid was achieved in a mixed gas system containing a 95 : 5 mixture of N 2 and CO 2 , even though the acids could not be distinguished by high‐field asymmetric waveform ion mobility spectrometry (FAIMS) when either pure N 2 or pure CO 2 was used as the carrier gas. Pseudomolecular anions of o ‐, m ‐ and p ‐phthalic acids were generated by electrospray ionization and detected, following separation by FAIMS, using a quadrupole mass spectrometer. Addition of small amounts of CO 2 to an N 2 carrier gas also caused the compensation voltages to increase by as much as 12 V, accompanied by 2–7‐fold improvements in the measured ion current and dramatic reductions in both adduct ion formation and parent ion fragmentation. Copyright © 2000 John Wiley & Sons, Ltd.