Premium
Fenvalerate treatment affects development of olfactory glomeruli in Manduca sexta
Author(s) -
Wegerhoff Rainer,
Rössler Wolfgang,
Higgins Mark,
Oland Lynne A.,
Tolbert Leslie P.
Publication year - 2001
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/1096-9861(20010219)430:4<533::aid-cne1048>3.0.co;2-d
Subject(s) - manduca sexta , biology , neuroscience , olfactory system , fenvalerate , antennal lobe , insect , ecology , pesticide
Low doses of fenvalerate, a widely used type‐II pyrethroid insecticide, have been shown previously to produce abnormal olfactory centers in the brain and abnormal olfactory‐mediated behavior in beetles (Wegerhoff et al. [1998] Neuroreport 9:3241–3245). Here, we use the experimental advantages of the moth Manduca sexta to explore the cellular changes that lead to these abnormalities. Our results indicate that treatment with fenvalerate may affect multiple aspects of the development of the primary olfactory centers, the antennal lobes, in Manduca , including ingrowth of olfactory receptor axons, axon fasciculation, and targeting within the antennal lobe, and intercellular signaling between the receptor axons and the glial cells that ordinarily surround and stabilize the developing olfactory glomeruli. J. Comp. Neurol. 430:533–541, 2001. © 2001 Wiley‐Liss, Inc.