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Cone mosaic development in the goldfish retina is independent of rod neurogenesis and differentiation
Author(s) -
Wan Jun,
Stenkamp Deborah L.
Publication year - 2000
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/1096-9861(20000724)423:2<227::aid-cne4>3.0.co;2-z
Subject(s) - biology , retina , cone (formal languages) , neurogenesis , opsin , mosaic , anatomy , neuroscience , phenotype , microbiology and biotechnology , rhodopsin , retinal , genetics , botany , history , archaeology , algorithm , computer science , gene
The goldfish retina displays a characteristic arrangement of cone photoreceptors that develop in a stereotyped sequence according to spectral phenotype. It has been suggested that the earliest differentiating photoreceptor in the teleost, the rod photoreceptor, might play an instructive role in development of the cone mosaic. This hypothesis was tested, first by examining the expression pattern of a cone subtype‐specific marker with respect to that of rod opsin, and then by killing the cells that generate rods and examining the cone mosaic that formed in the absence of new rods. We find that, although there is potential for interactions between developing cones and immediately postmitotic rods, a role for such interactions in cone mosaic pattern formation is not likely. J. Comp. Neurol. 423:227–242, 2000. © 2000 Wiley‐Liss, Inc.