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Comparative analysis of dendritic architecture of identified neurons using the Hausdorff distance metric
Author(s) -
Mizrahi Adi,
BenNer Eyal,
Katz Matthew J.,
Kedem Klara,
Glusman J. Gustavo,
Libersat Frederic
Publication year - 2000
Publication title -
journal of comparative neurology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.855
H-Index - 209
eISSN - 1096-9861
pISSN - 0021-9967
DOI - 10.1002/1096-9861(20000703)422:3<415::aid-cne8>3.0.co;2-t
Subject(s) - biology , metric (unit) , hausdorff distance , measure (data warehouse) , tree (set theory) , dendritic spine , computer science , artificial intelligence , neuroscience , mathematics , data mining , combinatorics , operations management , hippocampal formation , economics
Dendritic trees often are complex, three‐dimensional structures. Comparative morphologic studies have not yet provided a reliable measure to analyze and compare the geometry of different dendritic trees. Therefore, it is important to develop quantitative methods for analyzing the three‐dimensional geometry of these complex trees. The authors developed a comparison measure based on the Hausdorff distance for comparing quantitatively the three‐dimensional structure of different neurons. This algorithm was implemented and incorporated into a new software package that the authors developed called NeuroComp . The authors tested this algorithm to study the variability in the three‐dimensional structure of identified central neurons as well as measuring the structural differences between homologue neurons. They took advantage of the uniform dendritic morphology of identified interneurons of an insect, the giant interneurons of the cockroach. More specifically, after establishing a morphometric data base of these neurons, the authors found that the algorithm is a reliable tool for distinguishing between dendritic trees of different neurons, whereas conventional metric analysis often is inadequate. The authors propose to use this method as a quantitative tool for the investigation of the effects of various experimental paradigms on three‐dimensional dendritic architecture. J. Comp. Neurol. 422:415–428, 2000. © 2000 Wiley‐Liss, Inc.