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Reflectance spectroscopy for in vivo characterization of ovarian tissue
Author(s) -
Utzinger Urs,
Brewer Molly,
Silva Elvio,
Gershenson David,
Blast Robert C.,
Follen Michele,
RichardsKortum Rebecca
Publication year - 2000
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/1096-9101(2001)28:1<56::aid-lsm1017>3.0.co;2-l
Subject(s) - ovary , in vivo , ovarian cancer , reflectivity , pathology , spectroscopy , diffuse reflectance infrared fourier transform , chemistry , cancer , medicine , biology , optics , physics , biochemistry , microbiology and biotechnology , quantum mechanics , photocatalysis , catalysis
Background and Objective To explore whether reflectance spectroscopy can differentiate normal ovary, benign neoplasms, and ovarian cancer. Study Design/Materials and Methods Reflectance spectra (390–600 nm) were measured at three source‐detector separations (SDS) in vivo at 64 sites in 16 patients undergoing oophorectomy. Parameters with largest statistical differences were identified. Based on these parameters algorithms were developed and evaluated. Results Promising parameters were the reflectance intensity from 540 to 580 nm (SDS, 1.1 mm), the slope of the reflectance spectrum from 490 to 520 nm (SDS, 1.1 mm), the slope from 510 to 530 nm (SDS, 2.1 mm), and the slope from 510 to 530 (SDS, 3 mm). Average sensitivity and specificity were 86 ± 6% and 79 ± 5% to separate normal ovary from benign neoplasms and cancers. Average sensitivity and specificity were 86 ± 4% and 80 ± 8% to separate ovarian cancers from benign neoplasms and normal ovary. Conclusion Reflectance spectroscopy should be further investigated for ovarian cancer screening. Lasers Surg. Med. 28:56–66, 2001 © 2001 Wiley‐Liss, Inc.