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Effects of near‐infrared low‐level laser irradiation on microcirculation
Author(s) -
Maegawa Yasuyo,
Itoh Toshiyuki,
Hosokawa Toyoshi,
Yaegashi Kazuhiro,
Nishi Mayumi
Publication year - 2000
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/1096-9101(2000)27:5<427::aid-lsm1004>3.0.co;2-a
Subject(s) - microcirculation , arteriole , chemistry , in vivo , vasomotion , irradiation , vascular smooth muscle , vasoconstriction , medicine , vasodilation , biophysics , anatomy , biology , smooth muscle , physics , microbiology and biotechnology , nuclear physics
Background and Objective Recently, there has been an increase in the clinical application of low‐level laser irradiation (LLLI) in various fields. The present study was conducted to explore the effects of LLLI on microcirculation. Study Design/Material and Methods We investigated the effects of LLLI on rat mesenteric microcirculation in vivo, and on cytosolic calcium concentration ([Ca 2+ ]i) in rat vascular smooth muscle cells (VSMCs) in vitro. Results LLLI caused potent dilation in the laser‐irradiated arteriole, which led to marked increases in the arteriolar blood flow. The changes were partly attenuated in the initial phase by the superfusion of 15 μM L‐NAME, but they were not affected by local denervation. Furthermore, LLLI caused a power‐dependent decrease in [Ca ;2+ ]i in VSMCs. Conclusion The circulatory changes observed seemed to be mediated largely by LLLI‐induced reduction of [Ca 2+ ]i in VSMCs, in addition to the involvement of NO in the initial phase. Lasers Surg. Med. 27:427–437, 2000. © 2000 Wiley‐Liss, Inc.