Premium
Significantly increased lesion size by using the near‐infrared photosensitizer 5,10,15,20‐tetrakis ( m ‐hydroxyphenyl)bacteriochlorin in interstitial photodynamic therapy of normal rat liver tissue
Author(s) -
Rovers Jeroen P.,
de Jode Martin L.,
Grahn Michael F.
Publication year - 2000
Publication title -
lasers in surgery and medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.888
H-Index - 112
eISSN - 1096-9101
pISSN - 0196-8092
DOI - 10.1002/1096-9101(2000)27:3<235::aid-lsm5>3.0.co;2-t
Subject(s) - photosensitizer , photodynamic therapy , liver tissue , irradiation , chlorin , chemistry , laser , lesion , medicine , pathology , photochemistry , optics , physics , organic chemistry , nuclear physics
Background and Objective Penetration of tissues by activating light ultimately limits the size of the lesions achievable in interstitial photodynamic therapy. Measurements of the wavelength‐dependence of tissue optical properties suggest that substantial improvements may be possible, particularly in pigmented organs such as the liver, by using drugs absorbing at near infrared wavelengths. Study Design/Materials and Methods In this study, the extent of light induced necrosis with the photosensitive agents Photofrin (activated at 632 nm), meta‐tetra(hydroxyphenyl)chlorin (mTHPC) (activated at 652 nm) and 5,10,15,20‐tetrakis( m ‐hydroxyphenyl)bacteriochlorin (mTHPBC) (activated at 740 nm) are compared in normal rat liver. Interstitial irradiation of mTHPBC‐sensitized liver tissue resulted in significantly larger necrotic areas than irradiation of Photofrin and mTHPC‐sensitised livers. Conclusion The results illustrate the advantage of near‐infrared photosensitizer activation and point to a specific role for mTHPBC in the interstitial treatment of liver tumours. Lasers Surg. Med. 27:235–240, 2000. © 2000 Wiley‐Liss, Inc.