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Statistical analysis of diagnostic failure of fine needle aspiration cytology (FNAC) in breast cancer
Author(s) -
Tanaka Kanji,
Shoji Tetsuji,
Tominaga Yuji,
Nakagawa Hiroyuki,
Yamamoto Daigo,
Kawanishi Hiroshi,
Sakaida Noriko,
Okamura Akiharu,
Hioki Koshiro
Publication year - 2001
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/1096-9098(200102)76:2<100::aid-jso1019>3.0.co;2-v
Subject(s) - medicine , malignancy , univariate analysis , breast cancer , fine needle aspiration cytology , stage (stratigraphy) , cancer , pathology , multivariate analysis , estrogen receptor , cytology , oncology , radiology , biology , paleontology
Fine‐needle aspiration cytology (FNAC) was performed on 300 patients. Among those, 57 cases failed in accurate diagnosis of malignancy and 243 were successful. Fourteen clinicopathological factors altogether were analyzed to elucidate any correlation with FNAC failure using uni‐ and multivariate analysis. The univariate analysis in each clinicopathlogical factor showed that these error cases were vaguely palpable cancers, estrogen receptor (ER) positive cancers, small‐sized of tumors, scattered type of cancer cell distribution in tumor tissues, with low tumor grade, with low Nottingham prognostic index (NPI), with benign‐like ultrasound findings and with low TNM stage. The multivariate analysis revealed tumor grade was the strongest factor for all, followed by cellular distribution type of cancer cells and benign‐like ultrasound findings. From these results, we speculated that diagnostic failure of FNAC at first clinic visit seemed to be caused by mainly two histocytological factors: extrinsic factor (structural factor of tissue‐like tumor cells' distribution pattern etc.); and intrinsic one (cellular factor of low atypism such as benign‐like ultrasound finding, low tumor grade and so on). J. Surg. Oncol. 2001;76:100–105. © 2001 Wiley‐Liss, Inc.