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Prognostic significance of expression of thymidine phosphorylase and vascular endothelial growth factor in human gastric carcinoma
Author(s) -
Kimura Hironobu,
Konishi Kohji,
Nukui Takefumi,
Kaji Masahide,
Maeda Kiichi,
Yabushita Kazuhisa,
Tsuji Masahiko,
Miwa Atsuo
Publication year - 2001
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/1096-9098(200101)76:1<31::aid-jso1006>3.0.co;2-9
Subject(s) - thymidine phosphorylase , medicine , angiogenesis , immunohistochemistry , vascular endothelial growth factor , stage (stratigraphy) , carcinoma , metastasis , pathology , vascular endothelial growth factor c , neovascularization , oncology , vascular endothelial growth factor a , cancer , cancer research , vegf receptors , biology , paleontology
Background and Objectives Both thymidine phosphorylase (dThdPase) and vascular endothelial growth factor (VEGF) are well‐characterized inducers of angiogenesis. The purpose of this study was to examine the expression of these antigens and their prognostic significance in gastric carcinoma. Methods Medical records of 102 patients with stage II tumor were retrospectively reviewed. Primary tumors were studied by immunohistochemical staining for dThdPase and VEGF. Results Positive dThdPase expression was observed in 52 (51%) tumors and positive VEGF expression in 53 (52%) tumors. There was a significant correlation between the positive expression of VEGF and lymphatic invasion. The patients with dThdPase‐positive carcinoma showed a significantly worse prognosis than those with dThdPase‐negative carcinoma in stage II. Moreover, the frequency of hepatic recurrence was significantly higher in the patients with dThdPase‐positive and VEGF‐positive tumors than in those with dThdPase‐negative and VEGF‐negative tumors. Conclusions Combination analysis of dThdPase and VEGF expression in gastric carcinoma appears to be well‐characterized inductors of prognosis and metastasis. J. Surg. Oncol. 2001;76:31–36. © 2001 Wiley‐Liss, Inc.