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Treatment of childhood renal cell carcinoma with lymph node metastasis: Two cases and a review of literature
Author(s) -
Uchiyama Masanori,
Iwafuchi Makoto,
Yagi Minoru,
Iinuma Yasushi,
Ohtaki Masahiro,
Tomita Yoshihiko,
Hirota Masayuki,
Kataoka Satoshi,
Asami Keiko
Publication year - 2000
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/1096-9098(200012)75:4<266::aid-jso8>3.0.co;2-h
Subject(s) - medicine , nephrectomy , renal cell carcinoma , lymph node , dissection (medical) , adjuvant therapy , stage (stratigraphy) , metastasis , surgery , lymph , oncology , kidney , radiology , cancer , chemotherapy , pathology , paleontology , biology
Abstract Standard treatment for renal cell carcinoma (RCC) is radical nephrectomy with lymph node dissection. Stages I and II have encouraging prognoses, but Stage III with regional lymph node metastasis can be unfavorable. Adjuvant therapy for pediatric patients with advanced RCC with lymph node involvement or metastatic lesion has not been defined. Advanced pediatric RCC is reported in two patients (boys, aged 6 and 9 years: Stage IIIs, Robson; Stage III and IV, pTNM classification) treated by nephrectomy and lymph node dissection followed by postoperative interferon‐α (IFN), that can be used as an adjuvant therapy with side effects such as fever, bone marrow suppression, or decreased liver function. One is doing well for 7 years, another is suffered from lung metastases at 3 years after surgery. Although immunotherapy is expected to improve survival in pediatric patients with advanced RCC, surgical resection of renal and metastatic tumors remains the standard treatment. J. Surg. Oncol. 2000;75:266–269. © 2000 Wiley‐Liss, Inc.