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Erythrocytosis caused by an erythropoietin‐producing hepatocellular carcinoma
Author(s) -
Matsuyama Mitsuharu,
Yamazaki Osamu,
Horii Katsuhiko,
Higaki Ikko,
Kawai Shuichi,
Mikami Shinji,
Higashino Masayuki,
Oka Hiroko,
Nakai Takashi,
Inoue Takeshi
Publication year - 2000
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/1096-9098(200011)75:3<197::aid-jso8>3.0.co;2-i
Subject(s) - medicine , hepatocellular carcinoma , erythropoietin , hepatectomy , carcinoma , pathology , resection , surgery
A case of erythrocytosis caused by a hepatocellular carcinoma (HCC) that produced erythropoietin (Epo) is described. A 64‐year‐old man, with a huge HCC tumor in the right lobe of the liver, showed a high concentration of hemoglobin and increased levels of serum Epo, α‐fetoprotein (AFP), and protein induced by vitamin K absence II (PIVKA‐II). Right lobectomy of the liver was performed. Histological findings of the specimen showed a moderately differentiated HCC. The existence of Epo was confirmed immunohistochemically only in the tumor tissue and not in the normal liver tissue. Erythrocytosis disappeared and the serum levels of Epo, AFP, and PIVKA‐II returned to the normal range after the operation. Within 2 months after the operation, recurrent tumors appeared in the remnant liver, and the patient died 13 months after the operation. J. Surg. Oncol. 2000;75:197–202. © 2000 Wiley‐Liss, Inc.