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Fibromatoses of the extremities: Clinicopathologic study of 36 Cases
Author(s) -
Mehrotra Anupamjit K.,
Sheikh Salwa,
Aaron Alan D.,
Montgomery Elizabeth,
Goldblum John R.
Publication year - 2000
Publication title -
journal of surgical oncology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.201
H-Index - 111
eISSN - 1096-9098
pISSN - 0022-4790
DOI - 10.1002/1096-9098(200008)74:4<291::aid-jso10>3.0.co;2-f
Subject(s) - medicine , surgery , radiation therapy , adjuvant therapy , surgical margin , chemotherapy , resection
Background and Objectives Fibromatoses of the extremities are rare and often recalcitrant to treatment. We evaluated the clinical and pathologic features of a group of extremity fibromatoses treated by surgical excision with or without adjuvant therapy to determine if any clinical orpathologic parameters were predictive of clinical outcome. Methods Thirty‐six extremity fibromatoses were evaluated. Anumber of clinical and histologic features were correlated with risk of local recurrence. Results The cohort included 19 females and 17 males with ages ranging from 11–72 years (mean: 35 years), with 12 tumors of the upper and 24 tumors of the lower extremity. Tumors ranged insize from 1.5–15.5 cm (mean: 7.5 cm).Histologically, 26 were infiltrative, 3 had pushing borders and 7had both. Mitotic counts ranged from 0–5/50high‐power fields (mean: 0.74). Surgical marginswere positive in 22 cases. Seventeen patients were treated with postoperative adjuvant therapy including radiation therapy and tamoxifen. Follow‐up information was available in 34 cases (from 1–202 months; mean: 83 months). Nineteenpatients (56%) had recurrences, including 11 withmultiple recurrences (range to first recurrence: 5–61months; mean 23 months). Seventy‐one percent ofpatients with a positive surgical margin and clinical follow‐up had a local recurrence, compared to 31%with a negative surgical margin ( P < 0.05). None of the other clinical or histologic parameters correlated with the risk for local recurrence. Conclusions Local control in fibromatoses of the extremities remains problematic. Aside from positive surgical margins, none of the other clinical or histologic parameters evaluated in this study were useful in predicting the risk of local recurrence. J. Surg. Oncol. 2000;74:291–296. © 2000 Wiley‐Liss, Inc.