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Vaccinia reactive antibodies in a south Indian population
Author(s) -
Kannangai Rajesh,
Finny G. Joseph,
John T. Jacob,
Sridharan Gopalan,
Gopal Robin
Publication year - 2000
Publication title -
journal of medical virology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.782
H-Index - 121
eISSN - 1096-9071
pISSN - 0146-6615
DOI - 10.1002/1096-9071(200010)62:2<293::aid-jmv23>3.0.co;2-v
Subject(s) - vaccinia , virology , antibody , virus , orthopoxvirus , population , vaccination , titer , medicine , serology , biology , immunology , biochemistry , environmental health , gene , recombinant dna
The prevalence of vaccinia virus antibodies was determined in both urban and rural populations in southern India. The study sample consisted of 211 adults and 52 children. The antibody titre was measured in all sera by virus neutralisation and by indirect immunofluorescence assay (IFA). A small panel of sera was tested by Western blotting. There was no significant difference in detection rates between the tests. Generally, seropositivity correlated with a previous history of vaccination. All children were negative for vaccinia antibodies. Among adults overall, 54% had neutralising antibodies whereas 60% were positive for antibodies detected by IFA, however, the prevalence of vaccinia antibody by either method was significantly higher ( P < 0.001) among rural subjects than in urban subjects. This higher antibody prevalence among the rural population could be due to exposure to other indigenous orthopoxviruses, possibly buffalopox. J. Med. Virol. 62:293–297, 2000. © 2000 Wiley‐Liss, Inc.